Economics, ego and evangelism in science? Discuss! This has caused quite a stir amongst the scientific community. That many observations in biomedicine are hard to replicate, and the fact there is a lack of published ‘negative’ results (i.e. results that don’t support a hypothesis being ‘right) is hard to argue with…but what are the causes, and how much do they mirror wider problems in a modern society? And why the big green brain…envy?